Associations of Multiple Brain Pathologies and Clinical Dementia Progression
among Community-based Autopsy Cohort 
   Lead Investigator:    Mo-Kyung Sin
   Institution      :    Seattle University
   E-Mail           :    sinm@seattleu.edu
   Proposal ID      :    1225



   Proposal Description:
   The purpose of this study is to examine the role of each brain pathology (Cerebral amyloid angiopathy (CAA), hippocampasl sclerosis) in conjunction of AD pathology (Braak >2 and CERAD moderate or frequent) in the clinical progression of dementia (Clinical Dementia Rating Scale Sum of Boxes, MMSE)among community-dwelling autopsy cohort age > 65.     Combined effect of brain pathologies (CAA, hippocampal sclerosis, lewy bodies, microninfarcts, AD pathology) in the clinical progression of dementia controlling for age, Apoe 4 will be also examined.    Expected outcome: it is expected that AD pathology with hippocampal sclerosis will have the highest impact on the clinical progression of dementia. This study will provide us with foundational understanding on ways to prevent dementia progression.    Sub-aim: I will look at which cardiovascular risk factor (CHF, HTN, A fib, diabetes, hypercholesterol) is most significantly influence severity of dementia progression (measured by Clinical Dementia Rating - Sum of Boxes (CDR-SOB).